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- W2366027520 abstract "Objective To investigate the expressions and change of the Aβ oligomers in the brains of patients with Alzheimer's disease,and the expressions of TNF-α,MCP-1,MIP-1α and nAChRs in Alzheimer's disease cells model treated with diffenent Aβ aggregate forms.And to dicuss the role of them in the pathogenesis of AD.Methods Immunohistochemistry was used to determine the expressions of Aβ oligomers in the hippocampus,temporal cortex and frontal cortex of patients with AD and age-matched control subjects.ELISA was used to determine TNF-α,MCP-1,and MIP-1 expressions.Western blotting was used to determine α3,α7nAChRs expressions in each group cells in the Alzheimer's disease cellsmodel.Results The AβOs-like immunoreactivity was mainly expressed in cells.The expression of AβOs were observed in granular cells in the dentate gyrus,in axons of neunons in the hippocampus CA1-CA4 and the entorhinal cortex,as well as blood vessel walls of brains.As compared to control cases,increased expression of AβOs was detected in AD brains.When SHSY-5Y cells were treated with 1mol/L Aβ-oligomers,-monomer or-fibril for 48h,the significantly decreased protein levels of α3 and α7nAChR subunits and the increased levels of inflammatory fators were detected in the cultured cells treated with Aβ-oligomers as compared to the cells exposed to Aβ-monomer and-fibril.Conclusion The expressions of TNF-α,MCP-1 and MIP-1α were increased by Aβ Oligomers.The protein expressions of α3 and α7nAChRs were decreased by Aβ Oligomers,and AβOs maybe are the most important toxic form in the pathogenesis of AD." @default.
- W2366027520 created "2016-06-24" @default.
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- W2366027520 date "2011-01-01" @default.
- W2366027520 modified "2023-09-26" @default.
- W2366027520 title "Diffenent Aβ aggregate forms influence which expresses to the inflammatory factor and nerve Nicotine acetylcholine receptors" @default.
- W2366027520 hasPublicationYear "2011" @default.
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