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- W2366028288 abstract "Objective:To investigate the expression of thrombospondin-1 ( TSP-1) in prostate cancer and its relation to the angiogenesis.Methods:The expression of TSP-1 and microvessel density (MVD) were studied in 22 prostate cancer patients by using immunohistochemical technology, and reverse-transcriptase polymerase chain reaction analysis for TSP-1 mRNA in 7 cases prostate cancer tissues.Results:Positive expression of TSP-1 protein detected in 16(72.7) of the 22 cases. Most positive staining for TSP-1 were seen in the cytoplasm of the cancer cells, some were in the extracellular matrix. The mean MVD in 22 prostate cancer cases was 71.21±31.14 vessels per 100 high field of vision. Using RT-PCR analysis, we observed high levels of TSP-1 mRNA expression in 7 prostate cancer. Tumors with a high expression of TSP-1 showed a high MVD and the correlation between TSP-1 immunopositivity and microvessel density was highly significant(r=0.54, P=0.009).Conclusions:The TSP-1 is strongly expressed in most prostate cancer and were associated with neovascularization. TSP-1 is likely to contribute to the extensive neovascularization." @default.
- W2366028288 created "2016-06-24" @default.
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- W2366028288 date "2006-01-01" @default.
- W2366028288 modified "2023-09-25" @default.
- W2366028288 title "The expression of thrombospondin-1 in prostate cancer and its clinical significance" @default.
- W2366028288 hasPublicationYear "2006" @default.
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