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- W2366035067 abstract "In this study, the effects of biogenic amine in liquor on mice's drunken behavior and the 5-HT content in their brains were investigated. Firstly, the experimental models of dizzy drunken mice(intragastric administration of 48 %vol edible alcohol) were established, and the evaluation roles of field test, pole-climbing time, and righting reflex in the models were determined. 48 %vol edible alcohol was mixed with different concentration of histamine, tyramine, phenylethylamine, putrescine, serotonin, and mixed amine, behavior evaluation was carried out after 5 d continuous intragastric administration, and 5- HT content was measured after the final intragastric administration. The results showed that, the intragastric administration doses for mice's dizzy and mice's drunkenness were 10.0 m L/kg·bw and 15.0 m L/kg·bw respectively, and the combination of field test, pole-climbing time,and righting reflex could reflect mice's behavior; there was no significant difference in mice's behavior between intragastric administration of low-dose low-concentration biogenic amine and of 48 % alcohol(P0.05), however, gastric administration of high-dose high-concentration biogenic amine would excite mice but not easily result in mice's drunkenness(histamine and phenylethylamine), and tyramine and mixed amine would aggravate mice's drunkenness, there was no significant difference for other biogenic amine; 30 mins after gastric administration of histamine, mice's 5-HT content was obviously higher than that in blank group and model group(P0.05), gastric administration of tyramine group was close to normal mice group, and gastric administration of mixed amine group was obviously lower than blank group and model group(P0.05), and phenylethylamine, putrescine and serotonin groups had no significant difference with model group(5-HT content in all groups lower than normal mice group(P0.05))." @default.
- W2366035067 created "2016-06-24" @default.
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- W2366035067 date "2015-01-01" @default.
- W2366035067 modified "2023-09-27" @default.
- W2366035067 title "Effects of Biogenic Amine in Liquor on Mice's Drunken Behavior and the 5-HT Content in Thier Brains" @default.
- W2366035067 hasPublicationYear "2015" @default.
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