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- W2366064462 abstract "To investigate the mechanism of activation the lectin pathway of complement in IgA nephropathy,enzyme-linked immunosorbent assay was performed to detect mining level of serumal mannose-binding lectin(MBL);immunohistochemical method was performed to detect expression of MBL、MASP-1、C3、C1q、IgA and C5b-9 on renal specimens.Patients of IgAN were characterized into MBL-positive cases and MBL-negative cases by glomerular co-deposition of MBL and MASP,and were analyzed distinction of couch expressionition retrospectively.Glomerular deposition of MBL was observed in 22 of 53 cases(41.5%) with IgAN and showed a mesangial pattern.All MBL-positive cases,but none of the MBL-negative cases showed glomerular co-deposition of MBL-associated serine proteases,C3 and C5b-9.Among patients of IgAN,serum level of MBL did not show significant difference than unimpaired patients.Patients of IgAN with glomerular MBL deposition,pathology classification was not correlation with intension of MBL deposition.Intension of MBL deposition was positive correlation with IgA in patients of IgAN.MBL-positive cases have significantly more proteinuria and more attacking macroscopic hematuria as MBL-negative cases,which shows activation of the mero-lectin pathway of complement is significant in IgA nephropathy." @default.
- W2366064462 created "2016-06-24" @default.
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- W2366064462 date "2011-01-01" @default.
- W2366064462 modified "2023-09-23" @default.
- W2366064462 title "The role of activation of the lectin pathway of complement in pathogenesy of IgA nephropathy" @default.
- W2366064462 hasPublicationYear "2011" @default.
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