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- W2366072922 abstract "Objectives: To investigate the immune characteristics of rats infected with Echinococcosus multicularis (E.m) and its effects on the graft by using BN-to-LEW orthotopic liver transplantation (OLT) models. Methods: The rats were randomly divided into three groups as follows: Group A normal controls were produced by (OLT in the same strain) from LEW-to- LEW; Group B.strain controls were produced by (OLT in the different strain) form BN-to-health LEW; Group C: E.m stimulated group were produced by BN-to-LEW rat with E.m infection for 3 months; The OLT procedure was considered as succesed model when the LEW rat can be survived over 48 h. The LEW serum, liver graft, spleen samples were collected in 1, 3, 5, 7 days after OLT respectively. Eight LEW rats in each group were remained for observation of their the survival days. Results: The mean survival times for each group were (54.13±16.62)d for group A, (4.75±1.58) d for group B, (15.50±3.93) d for group C, respectively. The survival time had statistic difference. The pathology results indicated: (1) there were no rejection in group A; (2) in group B, there appeared class1 rejection in the third, class 2 rejection in the fifth and class 3 rejection in the seventh days repetitively after OLT in rats. (3) There were no rejection before the first 5 days in group C, but it were increased to class 1 rejection repectively in the seventh day. Conclusion: E.m Infection was beneficial to the survive after OLT, The models could be considered of a good platform for further study on the liver transplantation field, especially in relation to Echinococcosus infection." @default.
- W2366072922 created "2016-06-24" @default.
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- W2366072922 date "2006-01-01" @default.
- W2366072922 modified "2023-09-25" @default.
- W2366072922 title "Study on immune tolerance on orthotopic liver transplantation in the inbred rat infected with Echinococcosus multicularis" @default.
- W2366072922 hasPublicationYear "2006" @default.
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