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- W2366074080 abstract "Objective:To establish an HPLC-UV method for the assessment of pharmacokinetics and bioequiva- lence of terazosin.Methods:18 healthy Chinese male volunteers were randomized to administrate a single crossover dose of test or reference tablets(2 mg).The blood concentrations of terazosin from the volunteers at the certain time- points after the administration were measured by HPLC.The pharmaeokinetic parameters as well as relative bioavail- ability were analyzed based on variation analyses and two one-side t-test.Results:The main pharmacokinetic pa- rameters of terazosin were as follows:T_(max)(1.08±0.19)h and(1.08±0.19)h,C_(max)(320.49±44.82)ng·mL~(-1) and(316.03±45.40 )ng·mL~(-1),t_(1/2)(12.68±0.92)h and(12.97±1.33)h,AUC_(0→48)(2648.00±316.85)ng· h·mL~(-1)and(2618.67±334.38)ng·h·mL~(-1),AUC_(0→∞)(3002.46±322.25)ng·h·mL~(-1)and(2979.85± 341.96)ng·h·mL~(-1).Conclusion:The method is simple and reliable.The test formulation is bioequivalent to the reference formulation." @default.
- W2366074080 created "2016-06-24" @default.
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- W2366074080 date "2007-01-01" @default.
- W2366074080 modified "2023-09-25" @default.
- W2366074080 title "Studies on pharmacokinetics and bioequivalence of terazosin hydrochloride tablets" @default.
- W2366074080 hasPublicationYear "2007" @default.
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