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- W2366090075 abstract "Objective To study the anti HBV effect of the active principle of Styelec plicata in vitro. Methods The active principle of Styelec plicata was extracted and separated from the fresh organism. HBV transfected cells of the 2.2.15 cell line were coincubated with the active principle in different concentrations(64,32,16,8,4,2,1 mg·mL 1 ) in 96 well plates for 12 days. The titers of HBsAg and HBeAg in the supernatants of the culture medium were then determined and served as indices for assessing the anti HBV effect of the drug. The median toxic dose(TD 50 ) of the active principle for the cells were assayed with the MTT test. The therapeutic indices of the drug were also determined. Results The active principle of Styelec plicate was shown to have a relatively prominent inhibitory effect on the secretion of both HBsAg and HBeAg. The toxicity of the principle to the cells was low and its therapeutic indices were all greater than 10. Conclusion The active principle of Styelec plicata was shown to have an evident anti HBV effect in vitro." @default.
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- W2366090075 date "2005-01-01" @default.
- W2366090075 modified "2023-09-25" @default.
- W2366090075 title "The Inhibitory Effect of the Active Principle of Styelec Plicata on HBsAg and HBeAg in Vitro" @default.
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