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- W2366092706 abstract "To evaluate the effect of naphthoquine in treating falciparum malaria, 60 patients with falciparum malaria were randomly allocated to naphthoquine group (n=30) and artesunate group (n=30) in 1997. Naphthoquine was given for 1 day with a total dose of 1000?mg and artesunate was given for 5 days with a total dose of 600?mg. The mean fever_subsidence time (MFST) was ( 29.6±16.4 )h in naphthoquine group and ( 18.3±9.0 )h in artesunate group (t= 3.25 ,P 0.01 ). The mean parasite clearance time (MPCT) was ( 98.4±27.6 )h in naphthoquine group and ( 43.0±17.1 )h in artesunate group (t= 9.46 ,P 0.01 ).The cure rate of naphthoquine group was 96.7% , higher than that of artesunate group( 73.3% ), and recrudescence rate of naphthoquine group within a follow_up period of 28 days was 3.3% , lower than that of artesunate group ( 26.7% ) (χ 2= 6.40 ,P 0.01 ). No side effects were found except that slight nausea appeared in few patients in both groups. It is concluded that naphthoquine has a shorter MFST and MPCT, and a higher cure rate as compared with artesunate." @default.
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- W2366092706 date "2000-01-01" @default.
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- W2366092706 title "A Randomized_Controlled Study of Naphthoquine and Artesunate in the Treatment of Falciparum Malaria" @default.
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