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- W2366092743 abstract "Objective: To study the influence of bovine colostrums powder (BCP) to normal rats and diabetic rats and to study preventive effect of BCP on diabetes. Methods: (l)The solutions of three different doses of BCP were administered orally to normal rats and diabetic rats for 5 weeks. At the 1st, 2nd, 3nd, 4th, 5th week of BCP administration, body weight and blood glucose were measured. At the 5th week, blood lipids were determined besides the indices mentioned above. (2) The solutions of three different doses of BCP were administered orally to normal rats for 15 days. Then streptozocin (STZ) 55 mg/kg were injected in traperitoneally to the rats. At the 7th day of STZ injection, body weight, blood glucose were measured, and at the 14th day, blood triglyceride(TG), total cholesterol (TC) were determined besides the indices mentioned above. Water consumption was recorded at the 6th and 13th day after STZ injection. Results: (1) There were no influence of three different doses of BCP to blood glucose of normal rats. At the 4th week, blood glucose in three different doses of BCP groups with injection of STZ were lower than that in group with STZ injection only. The result at the 5th week was similar with that at the 4th week. Body weight, TG and HDL-C levels in groups with supplement of different dose BCP did not change compared with STZ-injected group without BCP supplement. At the 5th week, TC in group with administration of high-dose of BCP were lower than that in group with STZ injection only and were not higher than that in control group. (2) At the 7th and 14th days after injection of STZ, blood glucose in group with administration of middle-dose of BCP were lower than that in group with STZ injection only. Water consumption in the former group was less than in the latter group. Body weight and ratio of thymus to body weight in groups with supplement of different dose BCP did not increase compared with STZ-injected group without BCP supplement at the 14th day of STZ injection. There were no difference in blood triglyceride, cholesterol among all groups. Conclusion: (l)BCP could decrease blood glucose and TC of STZ-induced diabetic rats, and this effect was associated with dose and period of time. There were no influence of three different doses of BCP to blood glucose of normal rats. (2) Oral administration of middle-dose BCP for 15 days could decrease hyperglycemia and polydipsia in diabetic rats induced by injection of STZ." @default.
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- W2366092743 date "2006-01-01" @default.
- W2366092743 modified "2023-09-28" @default.
- W2366092743 title "Effect of bovine colostrums powder on experimental diabetic rats" @default.
- W2366092743 hasPublicationYear "2006" @default.
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