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- W2366097351 abstract "AIM:To synthesize and characterize the new isoandrographolide dioxalyl ester or dioxalyl amide derivatives and to study antitumor activity of some of the derivatives.METHODS:On the basis of the antitumor activity the structure characteristics of andrographolide,21 of the new isoandrographolide dioxalyl esters or dioxalyl amides were synthesized through the reaction of isoandrographolide with dioxalyl chloride,alcohols or amines.All of the compounds were identified by IR,~(1)H NMR,MS spectra and elemental analysis.The antitumor activity of some of the compounds were primarily studied.RESULTS AND CONCLUSION:3,19-di{(n-butylamine)carbonyl carboxyl}-O-iso-andrographolide was found to possess similar antitumor activity to andrographolide.Stuctural modification to andrographolide could lead to new chemical entity with the antitumor activity." @default.
- W2366097351 created "2016-06-24" @default.
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- W2366097351 date "2005-01-01" @default.
- W2366097351 modified "2023-09-27" @default.
- W2366097351 title "Synthesis and Antitumor Activity of Isoandrographolide Compounds" @default.
- W2366097351 hasPublicationYear "2005" @default.
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