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- W2366097957 abstract "Objective To use RNA interference(RNAi) technology to silence anti apoptosis gene survivin of human gallbladder carcinoma GBC-SD cells,and then to observe changes of survivin expressions and the sensitivity to doxorubicin.Methods Targeting survivin gene fragment was inserted into the carrier,and then the constructed recombinant plasmids were induced to GBC-SD cells.The mRNA and protein levels of survivin were detected with RT-PCR and Western-blotting respectively before and after transfection.The sensitivity to doxorubicin was detected with MTT before and after transfection.Results The recombinant plasmids were successfully constructed.After transfection of recombinant plasmid in GBC-SD cells,the mRNA and protein expressions of survivin were significantly reduced;meanwhile doxorubicin could significantly inhibit GBC-SD cell growth.Conclusion The RNA interference expression vectors targeting surviving,which down-regulate the expression of surviving,can enhance the sensitivity of GBC-SD cells to doxorubicin." @default.
- W2366097957 created "2016-06-24" @default.
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- W2366097957 date "2012-01-01" @default.
- W2366097957 modified "2023-09-23" @default.
- W2366097957 title "The effect of RNA interference on GBC-SD cells expression of survivin and the sensitivity to doxorubicin" @default.
- W2366097957 hasPublicationYear "2012" @default.
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