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- W236609865 abstract "Publisher Summary This chapter discusses the extraneuronal uptake and metabolism of 3H-l-noradrenaline in rabbit aorta. The major problem encountered in studying the extraneuronal uptake of noradrenaline is that this process is masked by the more prominent uptake and storage of NA by adrenergic nerve terminals. The effects produced by iproniazid were qualitatively similar to the effects of pargyline. In the method described in the chapter, the tissues were pretreated with 3 × 10−4 M to 1 × 10−2 M iproniazid for 25 min and then washed for pargyline. Iproniazid was 30 to 100 times less potent than pargyline. The highest concentration of iproniazid increased the amount of NM found after incubation of isolated media with 3H-l-NA. This may reflect merely a decrease in the deamination of NM rather than an actual increase in O-methylation of NA. The harmaline was left in contact with the tissue during incubation with 3H-l-NA. The most striking effect of harmaline was the decrease in the formation of all five metabolites of 3H-l-NA. It is found that because harmaline also increased the tissue accumulation of 3H-l-NA these effects probably result from inhibition of both MAO and COMT rather than from inhibition of extraneuronal uptake. Harmaline was a slightly more potent MAO inhibitor than pargyline." @default.
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- W236609865 date "1976-01-01" @default.
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- W236609865 title "EXTRANEURONAL UPTAKE AND METABOLISM OF 3H-l-NORADRENALINE IN RABBIT AORTA" @default.
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- W236609865 doi "https://doi.org/10.1016/b978-0-08-020540-3.50019-6" @default.
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