Matches in SemOpenAlex for { <https://semopenalex.org/work/W236612365> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W236612365 endingPage "6" @default.
- W236612365 startingPage "592" @default.
- W236612365 abstract "Basophils from many atopic persons, and especially asthmatic patients, have been shown to release histamine in response to 44% deuterium oxide (D2O), whereas basophils from nonatopic persons do not release histamine. The present experiments analyzed the mechanisms by which D2O mediated release. It was found that although D2O induced release from washed leukocytes, it failed to induce release from whole blood or from leukocytes that had sedimented but had not been washed. The kinetics of release after washing were rapid and were equivalent regardless of the temperature at which cells were sedimented (O degrees or 37 degrees C). Washed cells became desensitized to the action of D2O within 30 to 60 min at 37 degrees C, whereas unwashed leukocytes did not become desensitized. Serum or plasma inhibited D2O-induced release, although high concentrations (1/5) were less inhibitory than lower ones (1/10 to 1/100). Basophils from D2O responders also released histamine in response to a platelet enhancing factor (PEF), whereas those from D2O nonresponders did not. As with D2O-mediated release, PEF-mediated release occurred only with washed leukocytes, desensitized within 30 to 60 min at 37 degrees C, and was inhibited by serum. These results suggest that D2O induces histamine release by augmenting the effects of an endogenous activation mechanism, and that PEF acts on the same (D2O-responsive) donors to augment this activation mechanism. Cell activation, as well as desensitization of this activation mechanism, occurs rapidly when basophils are washed free of plasma inhibitors and placed at 37 degrees C." @default.
- W236612365 created "2016-06-24" @default.
- W236612365 creator A5004699609 @default.
- W236612365 creator A5007000396 @default.
- W236612365 creator A5016795268 @default.
- W236612365 creator A5035634631 @default.
- W236612365 creator A5087783336 @default.
- W236612365 date "1984-04-01" @default.
- W236612365 modified "2023-09-23" @default.
- W236612365 title "Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step." @default.
- W236612365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6201094" @default.
- W236612365 hasPublicationYear "1984" @default.
- W236612365 type Work @default.
- W236612365 sameAs 236612365 @default.
- W236612365 citedByCount "2" @default.
- W236612365 crossrefType "journal-article" @default.
- W236612365 hasAuthorship W236612365A5004699609 @default.
- W236612365 hasAuthorship W236612365A5007000396 @default.
- W236612365 hasAuthorship W236612365A5016795268 @default.
- W236612365 hasAuthorship W236612365A5035634631 @default.
- W236612365 hasAuthorship W236612365A5087783336 @default.
- W236612365 hasConcept C1122143 @default.
- W236612365 hasConcept C126322002 @default.
- W236612365 hasConcept C134018914 @default.
- W236612365 hasConcept C170493617 @default.
- W236612365 hasConcept C185592680 @default.
- W236612365 hasConcept C202751555 @default.
- W236612365 hasConcept C203014093 @default.
- W236612365 hasConcept C2776711897 @default.
- W236612365 hasConcept C2779779143 @default.
- W236612365 hasConcept C49039625 @default.
- W236612365 hasConcept C55493867 @default.
- W236612365 hasConcept C71924100 @default.
- W236612365 hasConcept C98274493 @default.
- W236612365 hasConceptScore W236612365C1122143 @default.
- W236612365 hasConceptScore W236612365C126322002 @default.
- W236612365 hasConceptScore W236612365C134018914 @default.
- W236612365 hasConceptScore W236612365C170493617 @default.
- W236612365 hasConceptScore W236612365C185592680 @default.
- W236612365 hasConceptScore W236612365C202751555 @default.
- W236612365 hasConceptScore W236612365C203014093 @default.
- W236612365 hasConceptScore W236612365C2776711897 @default.
- W236612365 hasConceptScore W236612365C2779779143 @default.
- W236612365 hasConceptScore W236612365C49039625 @default.
- W236612365 hasConceptScore W236612365C55493867 @default.
- W236612365 hasConceptScore W236612365C71924100 @default.
- W236612365 hasConceptScore W236612365C98274493 @default.
- W236612365 hasIssue "4" @default.
- W236612365 hasLocation W2366123651 @default.
- W236612365 hasOpenAccess W236612365 @default.
- W236612365 hasPrimaryLocation W2366123651 @default.
- W236612365 hasRelatedWork W1965692775 @default.
- W236612365 hasRelatedWork W1983315707 @default.
- W236612365 hasRelatedWork W2015308087 @default.
- W236612365 hasRelatedWork W2033668374 @default.
- W236612365 hasRelatedWork W2087998679 @default.
- W236612365 hasRelatedWork W2091557746 @default.
- W236612365 hasRelatedWork W2149663968 @default.
- W236612365 hasRelatedWork W2170031900 @default.
- W236612365 hasRelatedWork W2172131010 @default.
- W236612365 hasRelatedWork W2472219267 @default.
- W236612365 hasVolume "129" @default.
- W236612365 isParatext "false" @default.
- W236612365 isRetracted "false" @default.
- W236612365 magId "236612365" @default.
- W236612365 workType "article" @default.