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- W2366133033 abstract "AIM:To explore the effects of heparin on the expression of leptin and transforming growth factor β1(TGF β1) in rat hepatic stellate cells(HSCs). METHODS: HSCs were divided as follows: heparin groupⅠ(10 μg/mL), Ⅱ(100 μg/mL), Ⅲ(1 000 μg/mL), and control group. The incubation liquid was extracted after cultured 48 h and frosted in -20 ℃. Leptin and TGF β1 were detected by ELISA, the HSC proliferation was measured by MTT assay. RESULTS: The levels of leptin in heparin groupⅡ,Ⅲ were significantly lower than that in control group(P0.01). The level of TGF β1 and the mean absorbance in heparin groups were significantly lower than that in control group(P0.01). CONCLUSION: Heparin can decrease expression of leptin and TGF β1 in HSCs and inhibit proliferation of HSCs." @default.
- W2366133033 created "2016-06-24" @default.
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- W2366133033 date "2007-01-01" @default.
- W2366133033 modified "2023-09-24" @default.
- W2366133033 title "Effects of heparin on expression of leptin and transforming growth factor β_1 in rat hepatic stellate cells" @default.
- W2366133033 hasPublicationYear "2007" @default.
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