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- W2366146202 abstract "Objective:To study the expression of cyclooxygenase-2(COX-2) and nuclear factor-kappa B(NF-κB) protein in gastric carcinoma BGC-823 cells treated with basic fibroblast growth factor(bFGF),and to explore whether bFGF inhibits the apoptosis and promotes the proliferation of BGC-823 cells via Akt signal transduction pathway.Methods:Gastric carcinoma BGC-823 cells were cultured for serial passage and then treated with bFGF.The proliferation of BGC-823 cells was detected by MTT assay,and the activity of Akt and the expression of COX-2 and NF-κB protein were determined by Western blotting.Results:In BGC-823 cells treated with 25 ng/ml bFGF,Akt phosphorylation was activated,and the expression of p-Akt reached the peak at 10 minutes.The expression of COX-2 and NF-κB increased in a time-dependent manner and promoted the proliferation of BGC-823 cells.All the effects of bFGF were inhibited by wortmannin,an inhibitor of Akt.Conclusion:bFGF could induce the expression of COX-2 and NF-κB protein in gastric carcinoma BGC-823 cells via Akt signal transduction pathway,in which COX-2 and NF-κB closely correlate with the proliferation of BGC-823 cells." @default.
- W2366146202 created "2016-06-24" @default.
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- W2366146202 date "2007-01-01" @default.
- W2366146202 modified "2023-09-25" @default.
- W2366146202 title "Expression of COX-2 and nuclear factor-kappa B protein induced by bFGF via Akt signal transduction pathway" @default.
- W2366146202 hasPublicationYear "2007" @default.
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