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- W2366159054 abstract "OBJECTIVE:To investigate the association between the polymorphisms of TNF-α gene and the changes of T cell subsets and NK cells before and after the treatment of thymosin-alpha 1 in the intestinal tuberculosis (TB) patients.METHODS:66 cases of intestinal tuberculosis patients were treated with thymosin-alpha 1 plus the conventional anti-TB treatment.The levels of peripheral blood T cell subsets and NK cells were determined by flow cytometry.DNA was extracted from patients'peripheral blood and the genotypes of TNF-α-238,-308 polymorphisms were detected by PCR-RFLP.The correlation analysis between the polymorphisms and T cell subsets was performed by using SPSS software.RESULTS:After treatment with the conventional anti-TB therapy combined with thymosin-alpha 1 therapy,the statistical results at the end of 16 weeks showed that the detected values of CD3 + ,CD4 + ,CD8 + ,CD4 +/CD8 + ,and NK cells in patients with TNF-α-308 GA + AA genotype combination were significantly higher than before treatment,and the differences were statistically significant (P0.05); however,the detection on TNF-α-308 GG genotype and TNF-α-238 polymorphism showed no significant difference compared with before treatment (P0.05).CONCLUSION:There is a significant correlation between the polymorphisms of TNF-α gene and the alterations of T cell subsets in the intestinal tuberculosis patients treated with thymosin-alpha 1." @default.
- W2366159054 created "2016-06-24" @default.
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- W2366159054 date "2010-01-01" @default.
- W2366159054 modified "2023-09-25" @default.
- W2366159054 title "Association between the Polymorphisms of TNF-α Gene and Changes of T Cell Subsets in Patients with Intestinal Tuberculosis before and after Treatment with Thymosin-alpha 1" @default.
- W2366159054 hasPublicationYear "2010" @default.
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