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• W2366164096 abstract "Objective To study the effects of different distension pressures on the integrity of the endothelium of rabbit external jugular vein and on vein graft restenosis.Methods Rabbit external jugular veins were distended under pressure of 50?mm?Hg (group A,n=6,1?mm?Hg=0.133?kPa), 100?mm?Hg (group B,n=6) and 200?mm?Hg (group C,n=6) respectively. Then the veins were cut into 2 segments. One was for endothelial integrity grading by results of intravascular silver staining and SEM examination. The other was grafted end to end into the common carotid arteries. Twenty eight days post operatively, vein grafts were removed. Luminal area and intimal thickness of the vein grafts were calculated.Results Veins in group A showed mildest EC denudation. Its endothelium grade was significantly lower than in group B (1.42 vs 2.67, P0.01) and group C (1.42 vs 3.83, P0.01). Twenty eight days after implantation, all were patent except one in group C. The mean luminal area of vein grafts in group A was significantly larger than in group B [(11.3±2.0)?mm 2 vs (6.0±1.7)?mm 2,P=0.001] and group C [(11.3±2.0)?mm 2 vs (4.5±1.2)?mm 2, P0.001]. The intimal thickness of the vein grafts in group A was significantly lower than in group B [(36.2±3.4)?μm vs (52.3±7.7)?μm,P=0.001] and group C [(36.2±3.4)?μm vs (53.1±5.8)?μm, P0.001].Conclusion Distension pressure of 50?mm?Hg caused significantly milder restenosis than that of 100?mm?Hg and 200?mm?Hg. The explanation of the difference may be that it preserved the structural integrity of veins better than the other two." @default.
• W2366164096 created "2016-06-24" @default.
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• W2366164096 date "2002-01-01" @default.
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• W2366164096 title "Effects of distension on postoperative restenosis of rabbit external jugular vein graft" @default.
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