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- W2366166987 abstract "Background Previous studies have shown NOD2/CARD15 gene is the first susceptibility gene for Crohn′s disease(CD),and P268S has been identified to be possibly associated with CD in the Chinese population.Objective Our aims are to verify P268S which is associated with Chinese patients with CD and their clinical features.Methods Blood samples were obtained from 50 patients with CD,60 patients with ulcerative colitis(UC),and 100 healthy controls.We extracted DNA from patients′ white blood cells.The target sequence of NOD2/CARD15 was acquired by PCR amplification,the mutation was detected by PCR-RFLP and verified by direct DNA sequencing .Results Eight CD patients ,2 UC patients and 3 healthy controls were found to have P268S variant.The difference between CD patients and the other 2 groups was statistically significance(χ2 = 10.829,P = 0.004).The Clinical features of 8 CD patients were as follows: location of lesion of 7 patients were in the terminal ileum,1 was in the colon(χ2 = 8.936,P = 0.011).Six of them were younger than 20 years old(χ2 = 6.161,P = 0.013) and 6 of them had intestinal stricture which needs surgery(χ2 = 7.931,P = 0.005).Six of them were severe,2 were moderate(χ2 = 7.150,P = 0.028).Three of them were males,5 were females(χ2 = 1.296,P = 0.255).Conclusion P268S variant in NOD2/CARD15 is possibly associated with CD in Chinese population.P268S variant is related to the age of patients,the location of lesions,intestinal stricture and the state of illness,but not to gender." @default.
- W2366166987 created "2016-06-24" @default.
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- W2366166987 date "2008-01-01" @default.
- W2366166987 modified "2023-09-25" @default.
- W2366166987 title "NOD2/CARD15 gene mutation and Crohn′s disease in the Chinese population" @default.
- W2366166987 hasPublicationYear "2008" @default.
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