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- W2366187761 abstract "Trichloroethylene(TCE) is a widely-used industry solvent which has strong volatility and solubility and is ubiquitous in the environment.The epidemiology evidence showed that ever exposure to TCE may be associated with significantly increased risk of Parkinson's disease(PD).TCE can selectively cause dopaminergic neurodegeneration,which may be mediated by mitochondrial dysfunction,inflammation,oxidative stress and gathering of a-synuclein.In the mean time,trichloroacetaldehyde,one of the metabolites of TCE,can be combined with tryptamine in human body.The reaction forms a new chemical substance,1-trichloromethyl-1,2,3,4-tetrvahydro-b-carboline(TaClo),which is similar with MPTP in structure.TaClo has the ability to inhibit mitochondria complex 1 and cause damage to dopaminergic neurons.In summary,TCE may have strong relationship with the development of PD and the mechanism is still under exploration." @default.
- W2366187761 created "2016-06-24" @default.
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- W2366187761 date "2013-01-01" @default.
- W2366187761 modified "2023-09-24" @default.
- W2366187761 title "Trichloroethylene and Parkinson's Disease" @default.
- W2366187761 hasPublicationYear "2013" @default.
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