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- W2366213277 abstract "Objective: Through observing the influence of Astragaloside IV(AIV) and β-elemene on immunologic function of dentritic cells(DCs),we will discuss whether AIV and β-elemene coudle enhance the immunologic function of the organism through enhancing the function of DCs.It will provide the experiment basis of anti-tumor mechanism of AIV and β-elemene.Methods: D2SC cells were divided into five groups: control group,LPS group,AIV group,β-elemene group,AIV+β-elemene group and then treated with AIV and β-elemene in vitro.The surface molecules-MHCⅡ,MHCⅠ,CD40,CD80,CD86 and IL-6 and IL-12 were detected by methods of FCM and ELISA. Results: The level of surface molecules of D2SC cells(MHCⅡ、MHCⅠ、CD40、CD80、CD86) in AIV group or β-elemene group was higher than that in control group or LPS group,and the level of MHCⅡ in AIV group was obviously higher than that in the control group(P0.05),the levels of CD80、CD86 in β-elemene group were obviously higher than those in LPS group(P0.05).The levels of MHCⅡ,CD40 in AIV and β-elemene group were obviously higher than those in LPS group(P0.05) and the levels of MHCⅠ,CD86 were obviously higher than those in control group(P0.05).IL-6 or IL-12 level in the supernatant of D2SC cells of AIV or β-elemene group were higher than those in control group or LPS group.And the level of IL-12 and IL-6 in AIV or β-elemene group were obviously higher than those in the control group(P0.05).The levels of IL-12 and IL-6 in AIV and β-elemene group were obviously higher than those in LPS group(P0.05). Conclusion: AIV,β-elemene or combination of them can enhance the level of MHC cells and co-stimulatory factor in the surface of DCs.It also can promote the secretion of cytokine IL-12 and IL-6.So it can present antigen and induced the answer of T cells.The results supply immunological mechanisms for the method of Yiqihuoxue which combine AIV and β-elemene treating gastrointestina cancer." @default.
- W2366213277 created "2016-06-24" @default.
- W2366213277 creator A5019963637 @default.
- W2366213277 date "2011-01-01" @default.
- W2366213277 modified "2023-09-28" @default.
- W2366213277 title "Effects of Astragaloside IV and β-elemene on immunologic function of dentritic cells in rats" @default.
- W2366213277 hasPublicationYear "2011" @default.
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