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- W2366214677 abstract "To study ralationship beteen interteukin 2 (JL-2) and carcinoma open up a new field in tumor immunity. In this study, the method of modified rapid detection of IL-2 activity with mouse thymocyte was applied. IL-2 activity of peripheral blood was detected in 30 malignant lymphoma patients with 30 normal person. Patients received assay before and after COP scheme chemotherapy. The results show that pretherapeutic IL-2 activity value is 6.51±1.18 u/ml, and posttherapeutic .increase to 13.78±2.69 u/ml, but control's, 26.40±14.79 u/ml. To compare each other, the differences are highly significant (P0.01). The posttherapeu utic values and their increase degrees; of patients with stage Ⅲ-Ⅳ, partial response, and dead or tumor-bearing are lower than those with stage Ⅰ-Ⅱ (P0.02, P0.05), complete response (P0.05), and free (P0.01). There are no statistical significant (P0.05) in the values of patients with different courses, pathological types, and positive or negative extranodal involvm-e.nts. In the discussion, we have suggested that 1. decrease of IL-2 activity is a probable feature of all patients, with carcinoma; 2. tumor load perhaps plays a major role to suppress IL-2 activity; 3. chemotherapy may increase IL-2 activity with decrement of the dose of tumor load; 4. it is difficult to get rid of suppression to IL-2 activity with exacerbation of malignant lymphoma patients; 5. IL-2 activity assay may be able to become a index to predict prognosis of patients with carcinoma." @default.
- W2366214677 created "2016-06-24" @default.
- W2366214677 creator A5052883326 @default.
- W2366214677 date "1989-01-01" @default.
- W2366214677 modified "2023-09-23" @default.
- W2366214677 title "INTERLEUKIN 2 ACTIVITY VARIATION OF MALIGNANT LYMPHOMA PATIENTS RECEIVING CHEMOTHERAPY" @default.
- W2366214677 hasPublicationYear "1989" @default.
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