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- W2366220790 abstract "Objectives: To study the expressions of IL-8 mRNA, TSP-1 mRNA and their effects on the promoting or inhibiting angiogenesis of pancreatic carcinoma tissues. Methods: The assays of IL-8 mRNA, TSP-1 mRNA were detected by in situ hybridization techniques and the microvessel counts (MVC) was completed by immunohistochemical method of avidin-biotin complex on the 10% neutral formalin-fixed and routinely paraffin-embedded sections of 54 cases with pancreatic carcinoma. Results: The positive rate of IL-8 mRNA and TSP-1 mRNA was 59.3% and 55.6% respectively. The MVC was (64.2±11.8)/HP. The positive rates of IL-8 mRNA in the well-differentiated cases without metastasis were significantly lower than that in mediately or poorly-differentiated ones with metastasis, but that of TSP-1 mRNA was opposite. The MVC in the positive cases of IL-8 mRNA or the negative cases of TSP-1 mRNA was significantly higher than that in the negative ones of IL-8 mRNA or the positive ones of TSP-1 mRNA. The closely negative correlation was found between the expressions of IL-8 mRNA and TSP-1 mRNA. Conclusions: The expressions of IL-8 mRNA and TSP-1 mRNA might be closely related to the angiogenesis of pancreatic carcinoma tissues, IL-8 might have the promoting effect and TSP-1 might have inhibiting effect on the angiogenesis of malignant lesions." @default.
- W2366220790 created "2016-06-24" @default.
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- W2366220790 date "2004-01-01" @default.
- W2366220790 modified "2023-09-23" @default.
- W2366220790 title "Study on expressions of IL-8 mRNA, TSP-1 mRNA and their relationship with microvessel counts in pancreatic carcinoma tissues" @default.
- W2366220790 hasPublicationYear "2004" @default.
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