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- W2366240807 abstract "Objective:To explore the hepatic regeneration responses following stimultaneous resection of the hepar and the pancreas and the duodenum in an experimental animal model.Methods: Sixty SD rats were divided into four groups: 68% Hepatectomy group (Hx, n =15); Hx plus 50% partial pancreatectomy group (Hx plus Px, n =15); Hx plus duodenectomy group (Hx plus Du, n =15) and HPD group( n =15). Three rats in each group were sacrificed for blood and hepatic collection on 12,24,48,72 and 168 postoperative hours, respectively. PCNA labeled nuclei expression in the hepar was demonstrated immunohistochemically and the hepatic regeneration rate(LRR) was calculated. Results: The highest peak of PCNA expression of hepatocytes in the remaining lobes were markely reduced both on 24 hour after Hx plus Px and HPD, with a delay in the hepatic regeneration responses extending to 168 postoperative hour. Conclusion: Multifactors originated from the exocrine glands of the pancreas and the duodenum may play a distinct role in triggering hepatocyte proliferation." @default.
- W2366240807 created "2016-06-24" @default.
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- W2366240807 date "2002-01-01" @default.
- W2366240807 modified "2023-09-23" @default.
- W2366240807 title "Effect of Hepatopancreatoduodenectomy on Hepatic Regeneration in Rats" @default.
- W2366240807 hasPublicationYear "2002" @default.
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