Matches in SemOpenAlex for { <https://semopenalex.org/work/W2366245534> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2366245534 abstract "Advanced vulvar cancers involving midline structures pose a therapeutic challenge. Our objectives were to review the management and outcomes, and identify factors influencing primary treatment modality.Patients with midline vulvar cancers diagnosed from 1985 to 2012 were included in the analysis. Medical records were abstracted for demographics, clinico-pathological findings, treatment, and outcomes. Groin node status was defined by clinical findings or pathology. Survival was analyzed by Kaplan-Meier method and differences by log-rank test and Cox proportional hazards model. Factors influencing treatment modality were evaluated using stepwise logistic regression.Forty-two patients were identified. Twenty-one underwent primary radical vulvectomy and 21 underwent primary radiation. Median tumor diameter was 3.4cm (range 2-9cm) for primary radical vulvectomy and 5cm (range 2.3-15cm) for primary radiation. Primary radiation was significantly associated with a tumor diameter ≥5cm (p=0.02), or when 2 or more midline (p=0.008) or 1 or more mucosal structures (p=0.03) were involved. On multivariate analysis, age and tumor diameter were predictors of progression-free survival (PFS) (p=0.02 and p=0.0004, respectively) and overall survival (OS) (p=0.03 and p=0.0005, respectively). Thirty-month OS for primary surgery and primary radiation was 74% and 71% (p=0.78), respectively. There were no differences in PFS or recurrence rates between the two treatment groups.Clinical tumor diameter and the number of midline or mucosal structures involved influence selection of primary treatment modality. Survival outcomes and recurrence rates did not differ between treatment groups. Age and tumor diameter are important prognostic factors for survival." @default.
- W2366245534 created "2016-06-24" @default.
- W2366245534 creator A5020078669 @default.
- W2366245534 creator A5027975591 @default.
- W2366245534 creator A5037590677 @default.
- W2366245534 creator A5056864842 @default.
- W2366245534 creator A5065796046 @default.
- W2366245534 creator A5091030588 @default.
- W2366245534 date "2016-07-01" @default.
- W2366245534 modified "2023-09-25" @default.
- W2366245534 title "Factors influencing primary treatment of midline vulvar cancers" @default.
- W2366245534 cites W103824040 @default.
- W2366245534 cites W1561886278 @default.
- W2366245534 cites W1935824237 @default.
- W2366245534 cites W1951006848 @default.
- W2366245534 cites W1977357532 @default.
- W2366245534 cites W1982085611 @default.
- W2366245534 cites W1984066460 @default.
- W2366245534 cites W1989330291 @default.
- W2366245534 cites W1991449390 @default.
- W2366245534 cites W1992627421 @default.
- W2366245534 cites W2002721686 @default.
- W2366245534 cites W2008018346 @default.
- W2366245534 cites W2009096565 @default.
- W2366245534 cites W2009618057 @default.
- W2366245534 cites W2031222466 @default.
- W2366245534 cites W2044031515 @default.
- W2366245534 cites W2047370015 @default.
- W2366245534 cites W2061433239 @default.
- W2366245534 cites W2073122105 @default.
- W2366245534 cites W2079385788 @default.
- W2366245534 cites W2081153580 @default.
- W2366245534 cites W2082531833 @default.
- W2366245534 cites W2093426923 @default.
- W2366245534 cites W2106472384 @default.
- W2366245534 cites W2156281133 @default.
- W2366245534 cites W2403902526 @default.
- W2366245534 cites W2966290688 @default.
- W2366245534 cites W3109341 @default.
- W2366245534 doi "https://doi.org/10.1016/j.ygyno.2016.04.540" @default.
- W2366245534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27132089" @default.
- W2366245534 hasPublicationYear "2016" @default.
- W2366245534 type Work @default.
- W2366245534 sameAs 2366245534 @default.
- W2366245534 citedByCount "0" @default.
- W2366245534 crossrefType "journal-article" @default.
- W2366245534 hasAuthorship W2366245534A5020078669 @default.
- W2366245534 hasAuthorship W2366245534A5027975591 @default.
- W2366245534 hasAuthorship W2366245534A5037590677 @default.
- W2366245534 hasAuthorship W2366245534A5056864842 @default.
- W2366245534 hasAuthorship W2366245534A5065796046 @default.
- W2366245534 hasAuthorship W2366245534A5091030588 @default.
- W2366245534 hasConcept C10515644 @default.
- W2366245534 hasConcept C121608353 @default.
- W2366245534 hasConcept C126322002 @default.
- W2366245534 hasConcept C141071460 @default.
- W2366245534 hasConcept C143998085 @default.
- W2366245534 hasConcept C170964787 @default.
- W2366245534 hasConcept C207886595 @default.
- W2366245534 hasConcept C2779013556 @default.
- W2366245534 hasConcept C2780283643 @default.
- W2366245534 hasConcept C2780370617 @default.
- W2366245534 hasConcept C2780504313 @default.
- W2366245534 hasConcept C2908840091 @default.
- W2366245534 hasConcept C50382708 @default.
- W2366245534 hasConcept C509974204 @default.
- W2366245534 hasConcept C71924100 @default.
- W2366245534 hasConceptScore W2366245534C10515644 @default.
- W2366245534 hasConceptScore W2366245534C121608353 @default.
- W2366245534 hasConceptScore W2366245534C126322002 @default.
- W2366245534 hasConceptScore W2366245534C141071460 @default.
- W2366245534 hasConceptScore W2366245534C143998085 @default.
- W2366245534 hasConceptScore W2366245534C170964787 @default.
- W2366245534 hasConceptScore W2366245534C207886595 @default.
- W2366245534 hasConceptScore W2366245534C2779013556 @default.
- W2366245534 hasConceptScore W2366245534C2780283643 @default.
- W2366245534 hasConceptScore W2366245534C2780370617 @default.
- W2366245534 hasConceptScore W2366245534C2780504313 @default.
- W2366245534 hasConceptScore W2366245534C2908840091 @default.
- W2366245534 hasConceptScore W2366245534C50382708 @default.
- W2366245534 hasConceptScore W2366245534C509974204 @default.
- W2366245534 hasConceptScore W2366245534C71924100 @default.
- W2366245534 hasLocation W23662455341 @default.
- W2366245534 hasLocation W23662455342 @default.
- W2366245534 hasOpenAccess W2366245534 @default.
- W2366245534 hasPrimaryLocation W23662455341 @default.
- W2366245534 hasRelatedWork W2028444695 @default.
- W2366245534 hasRelatedWork W2366245534 @default.
- W2366245534 hasRelatedWork W2410466886 @default.
- W2366245534 hasRelatedWork W2418233823 @default.
- W2366245534 hasRelatedWork W2463421775 @default.
- W2366245534 hasRelatedWork W2464983764 @default.
- W2366245534 hasRelatedWork W3048057313 @default.
- W2366245534 hasRelatedWork W3113365735 @default.
- W2366245534 hasRelatedWork W4214554202 @default.
- W2366245534 hasRelatedWork W4244523620 @default.
- W2366245534 isParatext "false" @default.
- W2366245534 isRetracted "false" @default.
- W2366245534 magId "2366245534" @default.
- W2366245534 workType "article" @default.