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- W2366275045 abstract "Objective To study the effects of cornel iridoid glycoside (CIG) on the neurological function and expression of vascular endothelial growth factor (VEGF) and its receptor in rats with focal cerebral ischemia.Methods A total of 115 adult male Sprague-Dawley rats were randomly allocated into the sham operation, model and CIG (or treatment) groups. The latter was redivided into low-(20 mg/kg), medium-(60 mg/kg) and high-(180 mg/kg) dose groups (n=23 in each group). A rat model of focal cerebral ischemia was induced by middle cerebral artery embolization. Three hours after the model was established, the rats began to receive intragastric administration of CIG. Seven, 14 and 28 days after model making, the neurological function of rats was evaluated by the modified neurological severity score (mNSS), the expression of VEGF protein was detected by immunohistochemical method and Western Blot, and the expressions of the mRNA levels of VEGF and its receptor Flk-1 were assayed by reverse-transcriptase polymerase chain reaction (RT-PCR).Results ① Seven, 14 and 28 days after the model was established, the mNSS scores in the medium and high-dose CIG groups were decreased significantly as compared with the model group (F=2.832,F=4.970,F=2.661,all P 0.05). ②After seven days, there was no significant change in the expression of VEGF protein in the rat cerebral cortex between the model group and the sham-operation group; after 7, 14 and 28 days, the expression of VEGF protein in the rat cerebral cortex was decreased in the model group, while it was increased significantly in the CIG medium and high-dose groups as compared with the model group (F=1.202, F= 1.705,F=2.189, all P 0.05). ③Twenty-eight days after the model was established, the VEGF positive cell staining areas in the CIG and high-dose groups were increased significantly (F=13.249, all P 0.05). ④Seven days after model establishment, the expressions of the VEGF-mRNA in rat cerebral cortex were increased significantly in the CIG medium and high-dose groups as compare with the model group (F=2.389, all P 0.05). The expression of FLK-1 mRNA in the rat cerebral cortex in the CIG medium and treatment groups was also increased significantly (F=3.657, all P 0.05).Conclusion CIG improves the neurological function significantly in rat model with focal cerebral ischemia, and its mechanism may be associated with the expression of VEGF protein promoted by CIG." @default.
- W2366275045 created "2016-06-24" @default.
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- W2366275045 date "2009-01-01" @default.
- W2366275045 modified "2023-09-24" @default.
- W2366275045 title "Effects of cornel iridoid glycoside on the expressions of vascular endothelial growth factor and its receptor in rats with focal cerebral ischemia" @default.
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