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- W2366285250 abstract "Objective To investigate the effect of baicalin, the active ingredients of traditional Chinese medicine Scutellaria, in the prevention and control of periodontal diseases in clinical application. Methods One hundred patients of periodontal diseases in our hospital were selected and randomly divided into two groups, the LPS group and the baicalin+LPS group, each with 50 cases. Fifty healthy individuals treated with baicalin were enrolled as the baicalin group. Baicalin (0.1μg/ml) and LPS (100 μg/ml) were added correspondingly into the three groups on the basis of the basic medium. The cells were cultured in vitro in human periodontal ligament cells (PDLC). Thiazole salt colorimetric determination method was applied for the determination of PDLC by LPS-mediated proliferation effect, and flow cytometry was used to determine the impact of the PDLC by the LPS-mediated cell cycle. The difference between the three groups was compared. Results The OD value at A490 nm was (0.341±0.034) in the baicalin group, (192±0.023) in the LPS group, and (0.249±0.026) in the baicalin+LPS group. Statistically significant difference was found in the OD values between the three groups (P0.01). Conclusion The study of the active ingredients of traditional Chinese medicine Scutellaria provides significant basis for the prevention and treatment of periodontal diseases. In western Guangxi province, where the Chinese medicinal resources are rich and characterized by simple processing and low cost, the application and popularization of baicalin would bring about great social benefits." @default.
- W2366285250 created "2016-06-24" @default.
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- W2366285250 date "2012-01-01" @default.
- W2366285250 modified "2023-09-25" @default.
- W2366285250 title "Experimental study on the effect of baicalin, the active ingredients of traditional Chinese medicine Scutellaria, in the prevention and control of periodontal diseases" @default.
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