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- W2366291299 abstract "Objective: To explore the relationship between polymorphism in exon 7 (G894T) of the endothelial constitutive nitric oxide synthase (ecNOS) gene and the clustering of cardiovascular risk factors in patients with type 2 diabetes in Han nationality in Tianjin. Methods: Eighty type 2 diabetic patients without cardiovascular complication were recruited. The participants were all genetically unrelated. Genomic DNA was extracted from venous blood. The polymorphism of G894T was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: (1) The distribution of ecNOS genotype was in 63 cases in genotype GG group (78.75%), in 17 cases in genotype GT group (21.25%) and none in genotype TT group. (2) There was no significant difference in clinical and laboratory data between genotype GG and genotype GT group. (3) The more cardiovascular risk factors possessed in type 2 diabetic, the higher the proportion of GT genotype patients was, and there was a significant difference (χ2 = 7.544,P 0.05). Conclusion: The G894T polymorphism of ecNOS gene may be related with the clustering of cardiovascular risk factors in type 2 diabeties." @default.
- W2366291299 created "2016-06-24" @default.
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- W2366291299 date "2006-01-01" @default.
- W2366291299 modified "2023-09-26" @default.
- W2366291299 title "The Relationship of Endothelial Constitutive Nitric Oxide Synthase Gene Polymorphism and Clustering of Cardiovascular Risk Factors in Type 2 Diabetes" @default.
- W2366291299 hasPublicationYear "2006" @default.
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