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- W2366293227 abstract "Purpose This study was designed to explore the feasibility of EGFR mutation detection using mutation-specific EGFR antibodies(E746-A750del and L858R) by immunohistochemical Labvision in the human non-small cell lung cancer(NSCLC),and compare their sensitivity and specificity with the Roche 454 next-generation sequencing system.Methods EGFR mutation was assayed by immunohistochemistry using mutation-specific antibody and Roche 454 next-generation sequencing system in the randomly selected 68 cases of archived NSCLC tissues.Results EGFR mutations protein was localized in the cytoplasm and cell membrane of tumor cells.Immunohistochemical analysis showed that positive rates of EGFR mutation in the NSCLC tissues was 36.76%(25 /68),in which the mutation rate was 9.52%(2 /21) of squamous cell carcinoma,the mutation rate of adenocarcinoma was 48.94%(23 /47),significant difference was detected(P 0.05).Positive rate of EGFR mutations detected by Roche 454 next-generation sequencing system in the NSCLC tissues was 39.71%(27 /68),in which mutations in squamous cell carcinoma was 9.52%(2 /21),and the mutation rate of adenocarcinoma was 53.19%(25 /47),the difference was significant(P 0.05).Immunohistochemistry and Roche 454 next-generation sequencing to detect EGFR mutations have excellent consistency(Kappa = 0.876,P 0.001).Conclusion Immunohistochemcal with mutation-specific mAbs against EGFR is a promising,reliable prescreening method for EGFR mutations detection and rapid response EGFR-TKI therapy in NSCLC patients,which have lower testing costs,rapid reaction and easy diagnosed results,is a widespread method in the clinic." @default.
- W2366293227 created "2016-06-24" @default.
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- W2366293227 date "2014-01-01" @default.
- W2366293227 modified "2023-09-24" @default.
- W2366293227 title "Comparison between two methods of EGFR mutations detection in the human non-small cell lung cancer tissues" @default.
- W2366293227 hasPublicationYear "2014" @default.
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