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- W2366305681 abstract "Objective To observe the acute experimental allergic encephalomyelitis(EAE)in guinea pig peripheral blood mononuclear cells(PBMC)IFN-γ secretion,to explore its relationship with the incidence of EAE relevance.Methods 30 female guinea pigs were randomly divided into the normal control group,the EAE model group and the adjuvant control group,each having 10 Guinea pigs respectively.EAE was induced in guinea pigs by subcutaneous immunization with coarse myelin basic protein.The incubation period,aggressive-phase and clinical score were recorded on daily basis and changes of IFN-γ in culture supernatant were examined by ELISA method.Results EAE model group appears anorexia,weight loss,varying degrees of paralysis of limbs in about 2 weeks after vaccination,and showed a single course of disease incidence;normal control group and adjuvant control group did not,The release of IFN-γ by PBMC in the EAE model group is significantly higher than the normal control group(P0.05),while adjuvant control group compared with the normal control group,there was no significant difference(P0.05).The volume of IFN-γ released by PBMC in EAE model group was negatively correlated with incubation period(P0.05),however was positively correlated with aggressive-phase and clinical score(P0.05).Conclusion Immune imbalance exists in EAE Guinea pigs,IFN-γ secretion increased and correlated with the severity of disease." @default.
- W2366305681 created "2016-06-24" @default.
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- W2366305681 date "2010-01-01" @default.
- W2366305681 modified "2023-09-26" @default.
- W2366305681 title "The study of release of IFN-γ by peripheral blood mononuclear cells in guinea pig with experimental allergie encephalomyelitis" @default.
- W2366305681 hasPublicationYear "2010" @default.
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