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- W2366325483 abstract "AIM To study the effects of extracts of Ocimum basilicum L.on mouse peritoneal macrophages RAW264.7 and 5-lipoxygenase pathway.METHODS Effects of Ocimum basilicum L.extracts on growth of normal RAW264.7 cells and lipopolysaccharide-stimulated RAW264.7 cells by MTT colorimetric assay and the IC50 values were calculated to screen out the dose for administration.The lipopolysaccharide-induced RAW264.7 cells were intervened with Ocimum basilicum L.ethyl acetate extract and Ocimum basilicum L.butanol extract respectively.The concentrations of leukotriene B4 in the supernatant were measured by ELISA approach and the inhibition rate was calculated.RESULTS Ocimum basilicum L.ethyl acetate extract and Ocimum basilicum L.butanol extract inhibited on the growth of normal RAW264.7 cells,in which IC50 in 24 h were 312.5 μg/mL and 350.9 μg/mL respectively with concentration-dependent model.Both extracts had certain proliferation on growth of lipopolysaccharide-stimulated RAW264.7 cells(P0.05).The maximal inhibiting ratio were 42.78% and 38.63% respectively,and the inhibiting ratio of Ocimum basilicum L.ethyl acetate extract was stronger than that of Ocimum basilicum L.butanol extract(P0.05).CONCLUSION The experiment shows that maximal inhibiting concentration of Ocimum basilicum L.extracts to the growth of RAW264.7 cells reaches 100 μg/mL in relation to intracellular 5-lipoxygenase inhibitor in vitro." @default.
- W2366325483 created "2016-06-24" @default.
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- W2366325483 date "2013-01-01" @default.
- W2366325483 modified "2023-09-27" @default.
- W2366325483 title "Effect of extracts of Ocimum basilicum L. on mouse macrophage raw 264.7 and 5-lipoxygenase" @default.
- W2366325483 hasPublicationYear "2013" @default.
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