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- W2366335856 abstract "Objective To investigate the effects of angiotensinⅡ(AngⅡ) receptors antagonist on the LPS-induced acute lung injury (ALl).Method Wistar rats were randomly divided into three groups:control group;in LPS group,mrs were treated with LPS (10 mg/kg) at 3,6,12,and 24 hours;in LPS+ AngⅡreceptors antagonist group,pre-expasure to AngⅡreceptors antagonist [Sar~1,Ile~8] AngⅡfor 30 minutes before treated with LPS (10 mg/kg) for 6 hours.All the rats were killed,and the lung tissue was collected.Results Compared with control group pulmonary wet/dry weight ratio was significantly higher in the other two groups (P0.01),and the pulmonary microvascular protein leak,as assessed by Evans blue dye,significantly increased (P0.01).The histological exam showed that rats stimulated with LPS induced lung injury.The total pathological score was (12.00±2.45).Whereas [Sar~1,Ile~8] AngⅡcould significantly inhibit the acute lung changes induced by LPS at the 6 h time point.Conclusions AngⅡreceptors antagonist could protect tats from acute lung injury induced by LPS." @default.
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- W2366335856 date "2007-01-01" @default.
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- W2366335856 title "Protective effects of angiotensin II receptors antagonist on the LPS-induced lung acute injury" @default.
- W2366335856 hasPublicationYear "2007" @default.
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