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- W2366361244 abstract "Objective To explore the experimental therapeutic effect machanism of IL-18BP through binding endogenous IL-18 on ADR-induced nephropathy in mice.Methods The 30 KunMing mice were divided into 3 groups randomly:Blank group,Model group(ADR-MCN group)and Therapy group(IL-18BP group).The Model and Therapy group were induced to nephropathy model by single injection of ADR(7.5 mg/kg) through tail vena,and then the mice of Therapy group were treated with mIL-18 Binding Protein(mIL-18BP) with 0.5 mg/kg on day 5,7,12 and 21.Protein in uria was measured biweekly and objective sign of mice was recorded.All mice were sacrificed through getting blood from the heart on the 42 th day ater the first injection of ADR.Correlative cytokine and biochemical parameters were detected in serum.Results ①The 24hUPE of IL-18BP treated groups was significantly decreased as compared with that in ADR-MCN group,but still was significantly increased as compared with that in normal control(P0.01).②In ADR-MCN group,the levels of TG and TC were higher and TP and ALB were lower than those in IL-18BP theated groups in serum(P0.01).The levels of BUN and Scr had no significant difference(P0.05).③ In IL-18BP-treated groups,the level of IL-18 in serum was significantly decreased as compared with that in ADR-MCN group(P0.01) and positively correlated with 24 hUPE.Conclusions ①ADR Nephropathy Model induced.②IL-18BP has obvious therapeutic effect to ADR nephrosis mice through specifically binding IL-18,regulating immunologic balance,strengthening renal funtion." @default.
- W2366361244 created "2016-06-24" @default.
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- W2366361244 date "2009-01-01" @default.
- W2366361244 modified "2023-09-27" @default.
- W2366361244 title "Experimental study of IL-18 BP treatent in ADR-induced mice model of MCN" @default.
- W2366361244 hasPublicationYear "2009" @default.
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