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- W2366369935 abstract "Objective To study the high radiosensitivity of fibroblast cells (AT5BIVA cells) from the skin of the patients of ataxia-telangiectasia (AT). Methods Using conventional chromosome aberraton analysis method, chromosome aberration frequence( CAF) of AT cells and GM cells exposed to 60CO γ-rays was observed at doses of 0, 1, 2, 3 and 4 Gg, compared with that of GM 0639(GM cells) from the skin of the normal subject. The difference of CAF between AT cells and GM cells was analyzed, and dose-response curves were established. Results After exposed to 0, 1,2,3 and 4 Gy 60 CO γ-rays, theradiation-induced level of CAF was significantly higher in AT cells compared with GM cells (P0.05) . In the two cell types, CAF has a positive correlation with dose, and their linear regression equation is Y = a + bX. The slope of the CAF linear regression equation of AT cells is larger than that of GM cells (P0.05). Conclusion The radiosensitivity of AT cells is significantly higher than that of GM cells. AT cells is extremely sensitive to radiation." @default.
- W2366369935 created "2016-06-24" @default.
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- W2366369935 date "2004-01-01" @default.
- W2366369935 modified "2023-09-24" @default.
- W2366369935 title "Study on High Radiosensitivity of AT Cells by Conventional Chromosome Aberration Analysis Method" @default.
- W2366369935 hasPublicationYear "2004" @default.
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