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- W2366371951 abstract "Objective:To observe the effect of Guanxin decoction on MCP-1 and C-myc expression after percutaneous transluminal coronary angioplasty(PTCA) of rabbits.Methods:Endothelial injury models were established by using in-situ balloon expansion and strain-induced injury of rabbit carotid artery.The Guanxin decoction groups were fed correspondingly does 3 days before the operation.All the animals were sacrificed at the end of the 2ed,4th and 6th weeks respectively and operated carotid arteries were obtained.The expression of MCP-1 and C-myc mRNA were tested by RT-PCR.Results:The Guanxin decoction groups had lower levels of MCP-1、C-myc mRNA than model group(P0.05).And in the higher level of MCP-1、C-myc mRNA expression than shame group(P0.05).There are difference between the large-does group,the medium-does group,and the small-does group(P0.05).The large-does Guanxin decoction group had the lowest level at the end of the 6th week.Conclusion:Guanxin decoction could inhibiting decreased the expression of MCP-1、C-myc mRNA and the inhibition was dose-dependent.The mechanism of protect the injured artery by PTCA may relate to inhibiting the expressions of MCP-1、C-myc mRNA." @default.
- W2366371951 created "2016-06-24" @default.
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- W2366371951 date "2011-01-01" @default.
- W2366371951 modified "2023-09-24" @default.
- W2366371951 title "Effect of Guanxin Decoction on MCP-1 and C-myc Expression of Rabbits after Carotid Artery Balloon Injury" @default.
- W2366371951 hasPublicationYear "2011" @default.
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