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- W2366384964 abstract "Objective To design and synthesize small interfering RNAs(siRNAs) specific for interlukin-lβ(IL-lβ),and investigate the effects of different IL-1βsiRNAs on the expression of IL-1βmRNA in cultured rabbit fibroblasts and identify the effective one for constructing double strands RNA(dsRNA) specific for IL-1β.Methods Four sense and antisense siRNA oligonucleotide template specific for IL-1βwas designed by using Finder sequence software of the Ambion Company.Four IL-1βsiRNAs were transcribed in vitro and then transfected to rabbit fibroblasts.The mRNA levels of IL-lβin both transfected ceils and untransfected cells were evaluated by RT-PCR.Results The expression of IL-1βmRNA of fihroblasts transfected with IL-1βsiRNA(L4) was reduced significantly compared to the control group,and the other three siRNAs.Conclusions Different siRNAs designed to target the same IL-1βmRNA have different efficacy and one effective IL-1βsiRNA has been identified.The expression of IL-1βRNA of rabbit fibroblasts could be suppressed by RNA interference." @default.
- W2366384964 created "2016-06-24" @default.
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- W2366384964 date "2008-01-01" @default.
- W2366384964 modified "2023-09-25" @default.
- W2366384964 title "In Vitro Synthesis and Screening of Interlukin-1βSmall Interfering RNA" @default.
- W2366384964 hasPublicationYear "2008" @default.
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