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- W2366399716 abstract "Object To investigate the effects of human telomerase reverse transcriptase(hTERT) antisense phosphorothioate oligodeoxynucleotide (ASODN) on cell proliferation and cell cycle kinetics of Hela cell line in vitro. Methods We examined the effects of the growth of cell by MTT assay. Cell cycles were detected by flow cytometry(FCM) analysis technology. Results After treatment with ASODN of hTERT with different doses of 0.05 μmol/L, 0.1 μmol/L and 0.2 μmol/L respectively for 72 hours, the inhibitory growth rate of Hela cell was 6.74%, 13.12% and 22.01% respectively. ASODN of hTERT could change the cell cycle of Hela cell line, G0/G1 phase cells increased, S phase cells decreased and the proliferation index of Hela cell decreased. Conclusion In vitro, ASODN of hTERT possess inhibitory effects of proliferation and growth in Hela cell line and arrest the cell cycle progression in G0/G1 phase." @default.
- W2366399716 created "2016-06-24" @default.
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- W2366399716 date "2005-01-01" @default.
- W2366399716 modified "2023-09-23" @default.
- W2366399716 title "Effects of hTERT Antisense Oligonucleotides of Proliferation on Hela Cell Line in Vitro" @default.
- W2366399716 hasPublicationYear "2005" @default.
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