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- W2366416004 abstract "Objective To study the drug efficacy of the modified Naja naja atra venom(NNAV) in the treatment of immunosenescence. Methods C57BL/6 mice received oral administration of NNAV once a day for a year. Pictures of skin and hair in all mice were taken. The difference in learning and memory ability among each group of mice was detected by the Y maze electrical stimulation test. The difference in exercise tolerance among each group of mice was examined by the mouse running wheel fatigue measuring instrument. All mice were scarified after one year and the organs were accurately weighed and viscera index was calculated.Whole blood and serum were collected to examine routine blood test and blood biochemistry in hospital. The heart, kidney, skin and immune organs were HE stained and pathological changes were observed. Results The depilation phenomenon was significantly improved in NNAV-treated C57BL/6 mice(both 30 μg/kg and 100 μg/kg). Learning, memory ability and exercise tolerance were improved in NNAV-treated mice. Compared with the control group, the serum biochemical index and blood routine index(especially the immunerelated index) in NNAV-treated mice were significantly improved. Pathological changes showed that the injury and degradation of various organs(especially the immune organs) and inflammatory reaction were significantly lightened in NNAV-treated mice. Conclusion Oral administration of modified Naja naja atra venom for a long term played a role in deferring senility and delaying immunosenescence." @default.
- W2366416004 created "2016-06-24" @default.
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- W2366416004 date "2013-01-01" @default.
- W2366416004 modified "2023-09-23" @default.
- W2366416004 title "Drug efficacy study of Naja naja atra venom in the treatment of immunosenescence" @default.
- W2366416004 hasPublicationYear "2013" @default.
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