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- W2366418981 abstract "Objective To establish a multidrug resistance cell line of human bladder carcinoma and study the mechanism of multidrug resistance.Methods Human bladder carcinoma cell line T24 was induced to multidrug resistance cell line T24/ADM by intermittent administration of high dose ADM.The multidrug resistance was detected with MTT assay.The difference expressions of mdr-1 gene-coded P-glyeo protein(P-gp),multidrug resistance-associated protein(MRP),and LRP were examined with RT-PCR and Western blot.Results An adriamycin-resistant cell line T24/ADM was successfully established.It was cross resistant to many other chemotherapeutic agents,such as ADM,VCR and VP-16.The expression of P-GP, MRP and LRP were higher in multidrug resistance cell line than in parent line ADM.Conclusion T24/ADM was a model with multidrug resistance and the level of MDR mRNA expression were higher in T24/ADM than that in T24." @default.
- W2366418981 created "2016-06-24" @default.
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- W2366418981 date "2011-01-01" @default.
- W2366418981 modified "2023-09-24" @default.
- W2366418981 title "Establishment of a multidrug resistance cell line of human bladder carcinoma T24/ADM and its multidrug resistant mechanisms" @default.
- W2366418981 hasPublicationYear "2011" @default.
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