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- W2366426564 abstract "Objective:To confirm the residual leukemia of peripheral bone marrow by using bone marrow scintigraphy with Tc-99m-sulfur colloid and bone marrow aspirations.Method:Whole-body bone marrow scans was performed in 420 adults and 48 children acute leukemia patients after i.v. injection of 550~740 MBq of ~ 99m Tc-sulfur colloid. Comparative studies were performed in routine central bone marrow (CBM) aspiration at iliac crest and in expanded peripheral bone marrow (PBM) at proximal epiphyseal line of tibia.Result:The expansion rate of PBM in non-remission (NR) stage is 73.1 % and decreases to 56.6 % in complete remission (CR) stage. The most common expanded PBM sites are epiphysis and knee joint ( 74.5 %). Residual leukemia of peripheral bone marrow can be detected in aspirates from 30.9 % expanded PBM patients at early CR stage of CBM. CR of PBM ( 72.15 ± 32.54 days) is significantly delayed if compared with the CBM ( 42.5 ± 31.28 days) (P 0.01 ). No one got residual leukemia of PBM in children and non-expanded PBM patients. Relapse rate within 10 months in 74.4 % expanded PBM patients was significant higher than that in 13.6 % non-expanded PBM patients (P 0.01 ).Conclusion:The result shows the residual leukemia of CBM and PBM after chemotherapy is not always paralleled and synchronous. The expanded PBM is less sensitive to the chemotherapy due to less blood supply. It is apparently value to detect residual leukemia of PBM with bone marrow scintigraphy in treating leukemia patients." @default.
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- W2366426564 date "2006-01-01" @default.
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- W2366426564 title "Residual leukemia of peripheral bone marrow" @default.
- W2366426564 hasPublicationYear "2006" @default.
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