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- W2366440925 abstract "AIM: To investigate whether antioxidants modulate expression of endothelial cell adhesion molecules and inhibit adhesion of leukocytes to endothelium and furthermore, whether all antioxidants regulate NF-κB activation through a redox sensitive mechanism. METHODS:The effect of antioxidative substances dichloroisocumarin (DCI), chrysin, pyrrolidin dithiocarbamat (PDTC) and probucol on endothelial leukocyte adhesion under near physiological flow conditions were examined. The antioxidative activity of antioxidants was measured in a DCF fluorescence assay with flow cytometry. The activation of NF-κB in endothelial cells was investigated in a gel shift assay. RESULTS: PDTC and probucol did not show an inhibitory effect to the formation of intracellular H 2O 2 in TNFα activated human vascular endothelial cells (HUVEC), chrysin showed a moderate and DCI a strong antioxidative effect. In contrast, PDTC and chrysin inhibited the adhesion of HL60 cells. DCI and probucol did not have influence on the adhesion within the area of the examined shear stresses. Only PDTC inhibited the TNFα-induced activation of NF-κB in endothelial cells. CONCLUSION: The inhibition of endothelial leukocyte adhesion by antioxidative substances is not to be explained by its antioxidative characteristics only. The inhibitory effect of PDTC on NF-κB activation was probably not related to its antioxidative properties." @default.
- W2366440925 created "2016-06-24" @default.
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- W2366440925 date "1999-01-01" @default.
- W2366440925 modified "2023-09-25" @default.
- W2366440925 title "Inhibition of endothelial cell-leukocyte adhesion by Antioxidants is independent upon their antioxidative effect" @default.
- W2366440925 hasPublicationYear "1999" @default.
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