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- W2366454222 abstract "Objective To study the effect of arsenic trioxide(ATO)on the expression of anti-dsDNA antibody level and survival time of systemic lupus erythematosus(SLE)prone BXSB mice.The level of inter- leukin-4(IL-4),interferon-gamma(IFN-γ)secreted by spleen mononuclear cell in this SLE model is com- pared with C57 mice.Besides.the effect of ATO on the secretion of IL-4,IFN-γis also explored.Methods Forty-four BXSB mice were divided into two groups randomly.One group was treated with ATO bv intraperi- toneal injection for 3 months,while the other group was given the same wtume of normal saline.Then the con- centration of plasmic anti-dsDNA antibndy and survival time between ATO treated and untreated mice were compared.By eultivating spleen mononuclear cell in vitro,the effect of ATO on cell activity was detected with cell counter kit-8(CCK-8).And the level of IL-4,IFN-γin the supernatant was measured by enzyme-linked immunoadsordent assay(ELISA).So the level of IL-4,IFN-γsecreted by spleen mononuclear cells of BXSB and C57 mice could be compared.Furthermore,the level of IL-4,IFN-γsecreted by spleen mononuclear cells from BXSB miee of ATO treated anti untreated mice was also compared.Results ATO could significantly de- crease the serum anti-dsDNA antibody level in BXSB mice,but their survival time was not extended.The level of IL-4,IFN-γsecreted hy spleen mononuelear cells in BXSB mice was higher than C57 mice,ATO couht in- hibit the secretion.When the concentration of ATO was 1μmol/L,no effect on the activity of the cultivated cells could be observed.Conclusion The high level of IL-4,IFN-γplays an important role in the progress of SLE.ATO may be another effective immunosuppressive agent in treating SLE.Suppression the secretion of IL-4, IFN-γmay be one of its important mechanisms." @default.
- W2366454222 created "2016-06-24" @default.
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- W2366454222 date "2007-01-01" @default.
- W2366454222 modified "2023-09-26" @default.
- W2366454222 title "The change of survival length and dynamic secretion of interleukin-4 interferon-gamma induced by arsenic trioxide in lupus-prone BXSB mice" @default.
- W2366454222 hasPublicationYear "2007" @default.
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