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- W2366473081 abstract "OBJECTIVE To study the relationship between the expression of p16 and prognosis of patients with colorectal cancer(CRC).METHODS Streptavidin-Peroxidase immunohistochemical technique was applied to detect the expression of p16,in 120 cases of CRC.RESULTS The results showed that positive expression rate of p16 protein was 40.8%(49/120).P16 expression was related to the histological grade.With the reduction of tumor differentiation,the p16 positive expression rate was declining(χ2 = 5.463,P = 0.021).There were no significantly difference of p16 protein expression rates in different sex,age,tumor size,macroscopic configuration,tumor position,invasion depth of intestinal,lymph nodes metastasis and Dukes' classification(P﹥0.05).The expression of p16 was related to the 5 years prognosis of cases with CRC.The cases of p16 gene positive expression had much higher survival rate than those of negative expression(χ2 = 4.524,P = 0.033).CONCLUSION p16 seemed to be an important prognostic factor in the survival of patients with CRC." @default.
- W2366473081 created "2016-06-24" @default.
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- W2366473081 date "2012-01-01" @default.
- W2366473081 modified "2023-09-26" @default.
- W2366473081 title "Expression of p16 associated with survival time in colorectal cancer" @default.
- W2366473081 hasPublicationYear "2012" @default.
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