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- W2366477908 abstract "To observe the influences of ginsenoside Rg3(Rg3) and PEG-PLGA-Rg3slow-release nanoparticles(Rg3-N) on endothelial cells invasion and tube formation in vitro,and compared the difference.Methods The influences of Rg3 and PEG-PLGA Rg3-N on endothelial cells invasion and tube formation were observed by using transwell method and tube formation method,and the difference between effects of Rg3 and PEG-PLGA Rg3-N were compared.The gene and protein expressions of E-cadherins(E-cad),matrix metalloproteinase-9(MMP-9),hypoxia-inducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF) were detected by using RT-PCR and Western blot method for exploring the internal molecular mechanism.Results The treatment with Rg3 and PEGPLGA Rg3-N reduced significantly the invasive ability and tube formation of human EA.hy926 endothelial cells(P 0.05),had no significant influences on protein and gene expressions of VEGF,and decreased the expressions of MMP-9 and E-cad.There was no protein expression of HIF-1α observed in all groups.Conclusion The slow-release Rg3 and PEG-PLGA Rg3-N can inhibit the invasive ability and tube formation of human EA.hy926 endothelial cells through inhibiting the expressions of E-cad and MMP-9.PEG-PLGA Rg3-N can improve the antagonism ability to invasion and tube formation of human EA.hy926 endothelial cells in vitro." @default.
- W2366477908 created "2016-06-24" @default.
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- W2366477908 date "2014-01-01" @default.
- W2366477908 modified "2023-09-24" @default.
- W2366477908 title "Influences of nanoparticles Rg3 and PEG-PLGA-Rg3 on endothelial cells invasion and tube formation" @default.
- W2366477908 hasPublicationYear "2014" @default.
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