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- W2366508049 abstract "OBJECTIVE:To investigate the effects of different doses of trichloroethylene(TCE) on the expression alteration of SET gene at both the mRNA and protein levels, in order to provide some clues for the liver-injury mechanism of TCE. METHODS: Real-time quantitative PCR and Western blotting were employed to detect the mRNA and protein levels of SET in L-02 liver cells, which were separately treated with DMSO, 3 mmol/L and 10 mmol/L TCE. RESULTS: Compared with the control group, the mRNA and protein levels of SET were both significantly up-regulated (P0.01) in the L-02 liver cells treated with TCE, and the expression of SET protein in the 10 mmol/L TCE group was higher than 3 mmol/L TCE group, showing a dose-dependent relationship. CONCLUSION: TCE could induce the expression of SET at both the mRNA and protein levels in a dose-dependent manner, which indicated that SET might play an important role in the hepatotoxicity of TCE." @default.
- W2366508049 created "2016-06-24" @default.
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- W2366508049 date "2010-01-01" @default.
- W2366508049 modified "2023-09-23" @default.
- W2366508049 title "SET expression alteration in L-02 liver cells treated with trichloroethylene" @default.
- W2366508049 hasPublicationYear "2010" @default.
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