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- W2366510317 abstract "Objective To investigate the effect of Resina Draconis(RD)on the repair of skin defect treated with tissue engineering skin.Methods The tissue engineering skin was constructed with collagen sponge as the dermal scaffolds where human skin fibroblasts were transplanted inside and human keratinocytes were transplanted on the surface.Then the tissue engineering skin was transplanted into the skin wounds in naked mice with skin defects.After transplatation for 2 days,RD was used for the treatment.According to the administration method of RD,the treated mice were randomized into 3 groups:external-application RD group,oral-use RD group and combination group(external application and oral use of RD).A blank control group receiving tissue engineering skin transplantation alone was also set up.The differentiation tissue of the tissue engineering skin was sampled after transplantation for 9 days.And epidermal thickness of focal wound skin,laminin(Ln)and collagen typeⅠprotein expression in the dermis and the growth of the capillaries were observed.Results Resina Draconis promoted the development of epidermis and the growth of capillaries in dermis after transplantation of the tissue engineering skin,and increased the protein expression of Ln and collagen typeⅠ,the above effect being the best in the combination group.Conclusion Resina Draconis shows an enhancement on the repair of skin defect treated with tissue engineering skin." @default.
- W2366510317 created "2016-06-24" @default.
- W2366510317 creator A5090543058 @default.
- W2366510317 date "2009-01-01" @default.
- W2366510317 modified "2023-09-26" @default.
- W2366510317 title "Effect of Resina Draconis on the Repair of Skin Defect Treated with Tissue Engineering Skin" @default.
- W2366510317 hasPublicationYear "2009" @default.
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