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- W2366516465 abstract "Objective To discuss the elimination effect of Shuanghuanglian Injectable Powder and Qingkailing Injection on R plasmids of Escherichia coli(E.coli) producing super broad-spectrum β-lactamase(ESBLs) and influence on the activity of ESBLs.Methods E.coli with ESBLs positive were colleted from clinic and R plasmids were extracted with plasmid kit.The elimination of R plasmids was analyzed by using agarose gel electrophoresis and UV gel imager before and after the administration of Chinese medicinal.The extracting solution of ESBLs was collected by using ultrasonication and protein quantified by using Bradford method.The activity of ESBLs was determined taking Nitrocefin as substrate.Results Before and after the administration of Shuanghuanglian Injectable Powder and Qingkailing Injection,the comparison of plasmid maps showed that a plasmid band was lost.The activity of ESBLs was,respectively,(13.43 0.40) U/mg,(3.49 0.12) U/mg,(3.54 0.27) U/mg and(3.35 0.12) U/mg in broth group,Sulbactam group,Shuanghuanglian group and Qingkailing group.The activity of ESBLs decreased in Shuanghuanglian group and Qingkailing group compared with broth group(P0.01) and was similar to that in Sulbactam group.Conclusion Shuanghuanglian Injectable Powder and Qingkailing Injection have some elimination effects on R plasmids of drug-resistant E.coli and can inhibit the activity of ESBLs." @default.
- W2366516465 created "2016-06-24" @default.
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- W2366516465 date "2012-01-01" @default.
- W2366516465 modified "2023-09-22" @default.
- W2366516465 title "Influences of Shuanghuanglian Injectable Powder and Qingkailing Injection on R plasmids and β-lactamase of drug-resistant Escherichia coli" @default.
- W2366516465 hasPublicationYear "2012" @default.
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