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- W2366526583 abstract "Objective To evaluate the therapeutic efficacy of nucleoside analogs anti-viral treatment for liver cirrhosis with postoperative hepatocellular carcinoma(HCC).Methods 45 HCC cases with active liver cirrhosis were divided into treatment group and control group.22 cases under the control group had a hepatic transcatheter arterial chemoembolization(TACE) surgery and the 23 cases in the treatment group had TACE surgery followed by a one year nucleoside analog treatment.7 Patients were given Lamivudine(100mg PO QID and 16 Patients were given Entecavir(0.5mg PO QID).There was no difference in the conventional treatment between treatment and control groups.Results After 48 and 96 weeks of treatment,the decrease in HBVDNA level and the treatment response was better among the patients treated with Entecavir than Lamivudine.The HBV DNA negativity after 48 weeks of treatment was 71.4% and 81.2% in the Entecavir and Lamivudine treated patients,respectively(P0.05).The HBVDNA negativity was higher than the control group.Furthermore the liver function tests and the Child-Pugh scores were improved in the treatment group.The 48th and 96th weeks of survival were 78.2% and 60.8% in the treatment group,and 50.0% and 36.3% in the control group,respectively(P0.05).Conclusion The anti-viral treatment of HCC with active liver cirrhosis using Lamivudine and Entecavir effectively inhibits the replication of HBV and improves the patient's survival." @default.
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- W2366526583 date "2010-01-01" @default.
- W2366526583 modified "2023-09-23" @default.
- W2366526583 title "Treatment of liver cirrhosis with postoperative hepatocellular carcinoma with nucleoside analog" @default.
- W2366526583 hasPublicationYear "2010" @default.
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