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- W2366532126 abstract "Objective To investigate the efficacy and mechanism of action of Huoxue Jiedu Formula(HXJD) on spontaneous Sj(o|¨)gren's syndrome(SS) in non-obese diabetic(NOD) mice.Methods;Eighteen NOD/Ltj mice were randomly divided into a model group,HXJD group and a total glucosides of paeony(TGP) group,6 cases in each one,and 6 C57BL/6J mice were set as the normal group.The mouse submandibular gland and serum were get to detect the expression of toll-like receptor TLR4,CD14 mRNA and protein by reverse transcription polymerase chain reaction(RT-PCR) method and ELISA method respectively after 8 weeks of intragastric administration.Results Compared with the normal group,the expression of TLR4 and CD14 mRNA and protein in the model group was increased significandy(P 0.05);Compared with the model group,the expression of TLR4 and CD14 mRNA and protein in the TGP and HXJD group was significandy decreased(P 0.05);The expression of TLR4 and CD14 mRNA and protein between the TGP group and HXJD group had no significant difference(P 0.05).Conclusion HXJD has a better effect on SS for the NOD mice,and its mechanism might be related to the TLR4/CD14 signal transduction pathway." @default.
- W2366532126 created "2016-06-24" @default.
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- W2366532126 date "2014-01-01" @default.
- W2366532126 modified "2023-09-23" @default.
- W2366532126 title "Mechanism study of Huoxue Jiedu Formula on spontaneous Sjogren's syndrome in NOD mice" @default.
- W2366532126 hasPublicationYear "2014" @default.
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