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- W2366537302 abstract "The study was done to select the optimal formula,prepare and determine the mass concentration of long-acting oxytetracycline injection.The mass concentration of the approximate range in the oxytetracycline injection was determined through pre-test.The optimal formula of long-acting oxytetracycline injection is determined by using of orthogonal experiment.Prepare long-acting oxytetracycline injection and determine the mass concentration of long-acting oxytetracycline injection by UV spectrophotometry.The results showed that,the optimized formula of long-acting oxytetracycline injection(in 100 mL Volume) was composed of oxytetracycline hydrochloride 30 g,magnesium chloride 6g,sodium formaldehyde sulfoxylate 0.6g,complex organic solvent(composed by A glycerol acetaland polyethylene glycol 200)60 mL,polyvinylpyrrolidone(PVP) K17 7.5 g,ethanolamine 5.4 mL and water for injection.There is fine linear relationship for the mass concentration range which oxytetracycline hydrochloride unit is 5～30 mg/L.The average recovery was 97.86% and coefficient of variation was 1.15%.In conclusion,the production of long-acting oxytetracycline injection formula is reasonable and practical for stable potency and high recovery rate of oxytetracycline hydrochloride." @default.
- W2366537302 created "2016-06-24" @default.
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- W2366537302 date "2011-01-01" @default.
- W2366537302 modified "2023-09-25" @default.
- W2366537302 title "Formula Selection and Mass Concentraton Test of Long-acting Oxytetracycline Injection" @default.
- W2366537302 hasPublicationYear "2011" @default.
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