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- W2366539181 abstract "Objective To investigate the estrogenic activity and genotoxicity of organic extracts from water of Ganjiang River,and provide theoretically scientific basis for further environment risk assessment of Ganjiang River water pollution.Methods Water were sampled with amberlite XAD-120 separately at three site that located at upper,middle and down section of Ganjiang River,then the estrogenic activities of organic extracts were determined by uterotrophic assay in vivo;and the genotoxicity of such compounds was detected by micronucleus test.Results It was show that the estrogenic activity and genotoxicity of organic extracts from water of Ganjiang River were found in all samples,which were significantly higher than those of the vehicle controls(P0.01),and there was positive dose-response relationship.Organic extracts at different sections showed different estrogenic activities,the orders of estrogenic activities of those samples were as follows:upper sectionmiddle sectiondown section.Micronucleus rates in the groups treated with organic extract of down section water sample were higher than those of middle and upper sections with significant difference(P0.01);however,there was no difference between upper and middle sections.Conclusion It can been concluded that waters in Ganjiang River have been contaminated by endocrine disrupting chemical and have showed mutagenic effect in some extent,which might pose potential hazards to environment and population health." @default.
- W2366539181 created "2016-06-24" @default.
- W2366539181 creator A5087704995 @default.
- W2366539181 date "2009-01-01" @default.
- W2366539181 modified "2023-09-24" @default.
- W2366539181 title "Uterotrophic assay and micronucleus test on mice of organic extracts from water of Ganjiang River" @default.
- W2366539181 hasPublicationYear "2009" @default.
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